Tag Archives: Diagnostic Test

Discovery Of Biomarkers For Autism Could Lead To Diagnostic Test

Main Category: Autism
Article Date: 26 Mar 2012 – 2:00 PDT

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An important step towards developing a rapid, inexpensive diagnostic method for autism has been taken by Uppsala University, among other universities. Through advanced mass spectrometry the researchers managed to capture promising biomarkers from a tiny blood sample. The study has just been published in the prestigious journal Nature Translational Psychiatry.

There are no acknowledged biomarkers for autism today. Researchers at Berzelii Centre and the Science for Life Laboratory in Uppsala who, in collaboration with colleagues at Linnaeus University in Sweden and the Faculty of Medicine in Tehran, Iran, who have discovered some promising biomarkers.

Many diseases are caused by protein alterations inside and outside the body’s cells. By studying protein patterns in tissue and body fluids, these alterations can be mapped to provide important information about underlying causes of disease. Sometimes protein patterns can also be used as biomarkers to enable diagnosis or as a prognosticating tool to monitor the development of a disease. In the current study disruptions of the nervous system were in focus when the scientists studied protein patterns in autism spectrum disorder (ASD).

To identify potential biomarkers (peptides or proteins), the researchers performed a detailed protein analysis of blood plasma from children with ASD compared with a control group. Using advanced mass spectrometric methods, they succeeded in identifying peptides consisting of fragments of a protein whose natural function is in the immune system, the complement factor C3 protein.

The study is based on blood samples from a relatively limited group of children, but the results indicate the potential of our methodological strategy. There is already a known connection between this protein and ASD, which further reinforces the findings, says Jonas Bergquist, professor of analytical chemistry and neurochemistry at the Department of Chemistry – BMC (Biomedical Centre) in Uppsala.

The hope is that this new set of biomarkers ultimately will lead to a reliable blood-based diagnostic tool.

Article adapted by Medical News Today from original press release. Click ‘references’ tab above for source.
Visit our autism section for the latest news on this subject. Read the article. http://www.nature.com/tp/journal/v2/n3/full/tp201219a.html
Autism spectrum disorder is a collective name for neuropsychiatric disturbances that lead to functional impairment in at least two of the three areas that characterize autism:
-reciprocal social interaction
-reciprocal verbal and non-verbal communication
-imagination and behaviour

ASD comprises:
-Autism
-Asperger’s syndrome
-Disintegrative disorder (Heller’s syndrome)
-Atypical autism
The study was funded by the Swedish Research Council, among other financiers.
Uppsala University

Please use one of the following formats to cite this article in your essay, paper or report:

MLA

Uppsala University. “Discovery Of Biomarkers For Autism Could Lead To Diagnostic Test.” Medical News Today. MediLexicon, Intl., 26 Mar. 2012. Web.
28 Mar. 2012. APA

Please note: If no author information is provided, the source is cited instead.


posted by Living With Autistic Children on 26 Mar 2012 at 7:57 am

As a mother of triplets who are all on the spectrum I am keeping an eye on research because it may help my children in the future. It would be super if Autism could be detected with a blood test. Looking forward to hearing more about this down the road.

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‘Discovery Of Biomarkers For Autism Could Lead To Diagnostic Test’

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View the original article here

Discovery Of Biomarkers For Autism Could Lead To Diagnostic Test

Main Category: Autism
Article Date: 26 Mar 2012 – 2:00 PDT

email icon email to a friend   printer icon printer friendly   write icon opinions  

not yet rated5 stars
An important step towards developing a rapid, inexpensive diagnostic method for autism has been taken by Uppsala University, among other universities. Through advanced mass spectrometry the researchers managed to capture promising biomarkers from a tiny blood sample. The study has just been published in the prestigious journal Nature Translational Psychiatry.

There are no acknowledged biomarkers for autism today. Researchers at Berzelii Centre and the Science for Life Laboratory in Uppsala who, in collaboration with colleagues at Linnaeus University in Sweden and the Faculty of Medicine in Tehran, Iran, who have discovered some promising biomarkers.

Many diseases are caused by protein alterations inside and outside the body’s cells. By studying protein patterns in tissue and body fluids, these alterations can be mapped to provide important information about underlying causes of disease. Sometimes protein patterns can also be used as biomarkers to enable diagnosis or as a prognosticating tool to monitor the development of a disease. In the current study disruptions of the nervous system were in focus when the scientists studied protein patterns in autism spectrum disorder (ASD).

To identify potential biomarkers (peptides or proteins), the researchers performed a detailed protein analysis of blood plasma from children with ASD compared with a control group. Using advanced mass spectrometric methods, they succeeded in identifying peptides consisting of fragments of a protein whose natural function is in the immune system, the complement factor C3 protein.

The study is based on blood samples from a relatively limited group of children, but the results indicate the potential of our methodological strategy. There is already a known connection between this protein and ASD, which further reinforces the findings, says Jonas Bergquist, professor of analytical chemistry and neurochemistry at the Department of Chemistry – BMC (Biomedical Centre) in Uppsala.

The hope is that this new set of biomarkers ultimately will lead to a reliable blood-based diagnostic tool.

Article adapted by Medical News Today from original press release. Click ‘references’ tab above for source.
Visit our autism section for the latest news on this subject. Read the article. http://www.nature.com/tp/journal/v2/n3/full/tp201219a.html
Autism spectrum disorder is a collective name for neuropsychiatric disturbances that lead to functional impairment in at least two of the three areas that characterize autism:
-reciprocal social interaction
-reciprocal verbal and non-verbal communication
-imagination and behaviour

ASD comprises:
-Autism
-Asperger’s syndrome
-Disintegrative disorder (Heller’s syndrome)
-Atypical autism
The study was funded by the Swedish Research Council, among other financiers.
Uppsala University

Please use one of the following formats to cite this article in your essay, paper or report:

MLA

Uppsala University. “Discovery Of Biomarkers For Autism Could Lead To Diagnostic Test.” Medical News Today. MediLexicon, Intl., 26 Mar. 2012. Web.
28 Mar. 2012. APA

Please note: If no author information is provided, the source is cited instead.


posted by Living With Autistic Children on 26 Mar 2012 at 7:57 am

As a mother of triplets who are all on the spectrum I am keeping an eye on research because it may help my children in the future. It would be super if Autism could be detected with a blood test. Looking forward to hearing more about this down the road.

| post followup | alert a moderator |


‘Discovery Of Biomarkers For Autism Could Lead To Diagnostic Test’

Please note that we publish your name, but we do not publish your email address. It is only used to let you know when your message is published. We do not use it for any other purpose. Please see our privacy policy for more information.

If you write about specific medications or operations, please do not name health care professionals by name.

All opinions are moderated before being included (to stop spam)

Contact Our News Editors

For any corrections of factual information, or to contact the editors please use our feedback form.

Please send any medical news or health news press releases to:

Note: Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a health care professional. For more information, please read our terms and conditions.


View the original article here

Diagnosis and Definitions for Autism Spectrum Disorder

It is known there is no specific diagnostic test for Autism Spectrum Disorder, and the best way to get a diagnosis is to make a multi-disciplinary evaluation.

A psychologist or psychiatrist experienced with Autism Spectrum Disorders can make a diagnose for adults, and in what concerns children, they must be tested by a number of professionals, which will provide the needed information to make decisions about program and treatment approaches.

It was seen that the age of diagnosis ranges, depending on the circumstances from approximately 18 months through to adulthood.

Autism Spectrum Disorder deals with several labels, for example at an end of the spectrum there can be diagnoses like “Asperger Syndrome”, “High Functioning Autism” and “PDD-NOS”, and at the other end, we can find labels like “Autism”, “Classic Autism” and “Kanner Autism”. Several labels place people at different points of the spectrum.

We can say that the term Autism Spectrum Disorder is used because there is a great variation from person to person, which depends on the severity and combination of each area of impairment. It is known that together with Autism Spectrum Disorder may exist also other conditions or disorders, like speech and language disorders, anxiety and depression, intellectual disability, epilepsy, attention disorders, Tourette Syndrome and Down Syndrome.

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Usually, before the age of 3, in autism, clearly appear severe and sustained impairments in the social and communication areas. The child is observed as being different than other children, he is anxious, responds unusually to many different stimuli, has poor attention and motivation, and speech can be delayed or largely absent. The child can also have a range of ritualistic behaviours, like hand flapping, finger gazing or toe walking. It was seen that the child or adult with autism can be also intellectually disabled.

We can mention a loosely used term to describe a child or adult who meets the criteria for a diagnosis of Autism, but is not as severely affected as the more classically autistic person-High Functioning Autism.

Asperger Syndrome deals with severe and sustained social impairments, but the impairments in the language and communication area aren’t so severe. The speech develops within the normal age range, but effectively communication is impaired.

It was seen that the impairments become more evident as the child reaches pre-school and school age, being more subtle in the very young child.

There can also be given a diagnosis for children who present with some of the characteristics of either Autism or Asperger Syndrome, but not severe enough for a diagnosis of either of these conditions and this is Pervasive Developmental Disorder – Not Otherwise Specified.

More informations about autism causes or about autism symptoms can be found by visiting http://www.autism-info-center.com/
More informations about autism causes or about autism symptoms can be found by visiting http://www.autism-info-center.com/
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Asperger Syndrome – A Parent’s Guide

Nothing could be scarier to a father than hearing the diagnosis Asperger’s Syndrome. A lot is not known regarding this condition of the autism spectrum other than that it involves delays in essential skill improvement. These can contain delays in socialization and communication as well as other areas.

Although children with Asperger Syndrome do perform better than kids with traditional autism, you are still looking at a pervasive developmental disorder and your life will change as a result. Assistance is available as it is predicted that 2 out of every 10,000 kids born could  receive this diagnosis. Boys are 3 to 4 times more likely to have it and symptoms often appear by the third birthday.

Symptoms of Asperger Syndrome differ immensely. Your child might lack social skills or he might have communication difficulties. A bizarre gait might develop and your child may appear clumsy. Speech is often delivered in a monotone pitch with a shortage  of tempo or an strange modulation. Kids who have been diagnosed with this syndrome usually acquire an compulsive interest in a single area to the exclusion of all others. This can lead to poor communication with kids and adults alike.

If these symptoms are noticed in your kid, a medical expert will do any number of things. Currently there isn’t single diagnostic test to find out if this is the situation your kid has. As a result, you might get totally different diagnoses from different doctors. Nevertheless, all will most likely look for symptoms such as aloofness, a lack of interactive play, abnormal eye contact or a failure to react when called by name.

One or more have to be present by the age of three to receive this diagnosis. If your pediatrician suspects your child has Asperger Syndrome, the next step will be to have him evaluated by a team of professionals. This team might include a psychologist, a neurologist, a speech therapist and a psychiatrist in addition to other experts such as teachers. Probably, a whole neurological and genetic assessment will be done as well as cognitive and language testing. Then a diagnosis would be made.

Though a cure doesn’t exist for Aspergers Syndrome at this time, you do not have to despair. Help is available. Your son or daughter will need expert education as well as speech, physical, and/or occupational therapy. Behavior modification has been used with great success, using such techniques as positive reinforcement. Medication will not cure you kid, but you may receive prescriptions to help alleviate some symptoms. Social skills training are also frequently included in the treatment plan. Spend some time learning about the disorder and your options so you can best help your kid.

If you want to know what you wish to do when your kid has been diagnosed with aspergers, then visit http://www.parentingaspergerscommunity.com and take guidance from Dave Angel.
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